Academy Awards
Best Actress for 21 Grams (2003) – Nominated

American Film Institute
Best Actress for Mulholland Drive (2001) – Nominated

Chicago Film Critics Association
Best Actress for King Kong (2005) – Nominated
Best Actress for 21 Grams (2003) – Nominated
Best Actress for Mulholland Drive (2001) – Win

L.A. Film Critics Association
Best Actress for 21 Grams (2003) – Win
Best Actress for Mulholland Drive (2001) – Win

London Film Critics Association
Best Actress for King Kong (2005) – Nominated

National Board of Review
Breakthrough Performance of the Year for Mulholland Drive (2001) – Win

National Society of Film Critics
Best Actress for Mulholland Drive (2001) – Win

Online Film Critics Association
Best Actress for King Kong (2005) – Nominated

Screen Actors Guild
Best Actress for 21 Grams (2003) – Nominated